Abstract
Sulfation activity (Sm) and transferrin (Tf) were measured in 90 plasma samples from 39 children with CD classified 5 to 1 by intestinal biopsy performed at time of sampling : 10 before, 58 during gluten-free diet (GF), 22 after gluten reintroduction (GR). Sm was 0.32 ± 0.04 U/ml before GF, increased with GF from stages 5 to 1, to reach 1.23 ± 0.15, decreased at GR to 0.38 ± 0.06. Sm correlated to GF duration (r = 0.781). Correlation of Sm with growth velocity (V) was lacking at stages 5 to 2, and appeared at stage 1 (r = 0.778) . Tf decreased from a high value of 3.62 ± 0.15 g/l at stage 5 to 2.97 ± 0.14 after GF at stage 1, rising to 3.35 ± 0.10 at GR. Tf correlated negatively with GF duration (r = -0.720) and positively to V on GF (r = 0.492) and GR (r = 0.601). Longitudinal studies from GF to GR and again GF confirmed the inverse trend of Sm and Tf variations. These data show that early catch-up growth in CD treated with GF does not relate to sulfation activity and may involve other factors, such as Tf.
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Martinez, M., Donnadieu, M., Alonso, M. et al. Somatomedin and transferrin in celiac disease (CD). Pediatr Res 15, 1553 (1981). https://doi.org/10.1203/00006450-198112000-00106
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DOI: https://doi.org/10.1203/00006450-198112000-00106