Abstract
To study the effect of chronic administration of L- Dopa on growth 10 pairs of rats, matches by sibship and sex were injected 5mg/kg Dopa, or saline s.c. twice daily, from 3 to 13 weeks of age. Pair feeding was assured. At 13 weeks, after 2 days off treatment the animal were sacrificed. Blood was collected for GH RIA and the thymus, thyroid, adrenals, uterus and gonads weighed. Female and male rats grew significantly better on L-Dopa:
Serum GH was 8.44=1.4ng/ml in the Dopa and 4.6=0.9 in the control group. All organs weighed tended to be heavier in the Dopa group, though not significantly. In conclusion: Chronic administration of L-Dopa produce a chronic stimulation of GH secretion and enhances growth in male and in female rats.
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Greif, Z., Benderli, A., Hochberg, Z. et al. Growth response to chronic treatment by Dopa in rats. Pediatr Res 15, 1552 (1981). https://doi.org/10.1203/00006450-198112000-00104
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DOI: https://doi.org/10.1203/00006450-198112000-00104