Abstract
28 GHD patients aged 3-10 yrs. were treated with hGH (Roos-Kabi) during 1-4yrs. without pubertal interference. Dosages were 2mg in D1(N=19) and 4mg in D2(N=9), 3 times/week.11 patients received treatment during 4 full yrs.:6 in D1(rD1) and 5 in D2(rD2).The mean Chronological Age(CA),Bone Age(BA),Height(Ht)SDS*and BA.SDS were comparable in both groups at the onset of treatment. 1.-The evolution of height showed that in D2/rD2 the increase in SDS was significantly higher than in D1/rD1 through the treatment.The catch-up period was 3 yrs. in D1/rD1 and it was still present in D2/rD2 in the 4th yr. 2.-In D1/rD1 the BA increased parallely to the CA,but is the D2/rD2 there was a continuous catch-up of BA with BA>CA in the 4th yr. 3.-The relationship ΔHt/ΔBA was :
Whether this expected early bone fusion using the D2 dosage is due to the hGH itself or to a contamination by TSH/Gonadotrophins is now being investigated.
*SDS = Standard Deviation Score
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Vicens-Calvet, E., Vendrell, J., Albisu, M. et al. The dosage dependency on growth and maturity in growth hormone deficiency(GHD) treated with human growth hormone(hGH). Pediatr Res 15, 1552 (1981). https://doi.org/10.1203/00006450-198112000-00100
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DOI: https://doi.org/10.1203/00006450-198112000-00100