1728 LUNG WATER AND VASCULAR PERMEABILITY-SURFACE AREA IN LAMBS WITH HYALINE MEMBRANE DISEASE (HMD)

Abstract

HMD is associated with increased intrapulmonary shunting and clinical evidence of increased vascular permeability. Multiple-tracer methods were used to measure vascular permeability-surface area (PS) for 14C-urea using the integral extraction method in premature newborn lambs delivered by cesarean section (CS). Fourteen studies were performed during the first 7 hours after birth in 7 HMD lambs delivered at 127-133 days of gestation using 51Cr-erythrocytes, 125I-albumin and 14C-urea. Pulmonary blood flow was corrected for extra-pulmonary shunts using a flowcuff and microspheres. Extravascular lung water content (ELW) was measured post mortem with a 51Cr-erythrocyte method. The results were compared with those from 12 identical studies in 5 lambs without HMD delivered by CS around 140 days. Normalized to dry lung weight, the data expressed as mean ± S.E.M. were as follows:

Normalized this way, lung water was significantly greater in the HMD lambs. PS values were significantly lower in the HMD lambs and showed a significant* decrease with postnatal age. PS was inversely correlated to pulmonary vascular resistance (r=0.67*). These data indicate that pulmonary edema and derecruitment occurs in HMD resulting in decreased surface area for exchange. *p<0.05

Author information

Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Sundell, H., Brigham, K., Green, R. et al. 1728 LUNG WATER AND VASCULAR PERMEABILITY-SURFACE AREA IN LAMBS WITH HYALINE MEMBRANE DISEASE (HMD). Pediatr Res 15, 731 (1981). https://doi.org/10.1203/00006450-198104001-01747

Download citation

Further reading