Abstract
An antimeningococique vaccine prepared with polysaccharide C of Nesseria meningitidis was applied to volunteers from the staff of Hospital de Niños, Buenos Aires. Out of a total of 115 persons, 59 were vaccineted and the other 56 received placebo. The cases were matched by professional activity (nurses, resident doctors, staff doctors and other personnel) and by more or less direct contact with children with meningococcal diseases. The evaluation of the vaccine was carried out by the study of antipolysaccharide C antibodies (passive hemaglutination). One month later 73.2% of vaccinated had increased the antibodies in 2 or more dilutions (66.1% in 3 or more). Only 4% of controls had increased antibodies in 2 dilutions. The Geometric Mean (GM) of vaccinated was 5.5 before and 33.5 one month after vaccination. The GM increased only from 5.35 to 6.02 in controls. One year after vaccine, the GM of vaccinated was 31.34 and even 3 years later there were a significant difference between vaccinated and controls (GM 22.01 and 10.2). Neither professional activity nor the contact with sick children showed differences in the evolution of antibodies.
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Manterola, A., Tisminetzky, S., Grinstein, S. et al. 22 ANTIMENINGOCOCIQUE C. VACCINE EFFICACY. Pediatr Res 15, 186 (1981). https://doi.org/10.1203/00006450-198102000-00079
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DOI: https://doi.org/10.1203/00006450-198102000-00079