Abstract
We examined the effect of chronic hyperinsulinemia on lung lavage phospholipid (PL) content and composition. I (19 U/d for 20 d) was administered to fetal rhesus monkeys with an Alzet minipump implanted in the hind leg (Diabetes 28: 1058, 1979). Shamand non-operated animals were used as controls (C). X (5-10 mg/d for 20 d) was administered to additional mothers. Fetuses were delivered by cesarean section at 134-147 d (term is 165 d). I levels were 49±14 and 4470±780 μU/ml and glucose levels were 43±6 and 21±6 mg/dl in the C and I-treated groups respectively. Results are shown in the table. Hyperinsulinemia did not inhibit surfactant production. This suggests that the increased incidence of RDS in infants of diabetic mothers may not be due to hyperinsulinemia but rather possibly to the concomitant hyperglycemia. X increased surfactant production. X may be useful in the prevention of RDS in humans.
Supported by HD-11018 and HD-11343.
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Rooney, S., Gross, I., Marino, P. et al. 1715 EFFECT OF INSULIN (I) AND ISOXSUPRINE (X) ON LUNG SURFACTANT PRODUCTION IN THE FETAL RHESUS MONKEY. Pediatr Res 15 (Suppl 4), 729 (1981). https://doi.org/10.1203/00006450-198104001-01734
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DOI: https://doi.org/10.1203/00006450-198104001-01734