1651 THE PRETERM BABOON WITH HYALINE MEMBRANE DISEASE (HMD) AS A MODEL FOR BRONCHOPULMONARY DYSPLASIA (BPD)

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Abstract

BPD could be produced clinically and confirmed pathologically in preterm neonatal baboons (Papio cynocephalus) with HMD who were supported with mechanical ventilation (IPPV) and treated with 100% O2 for >1 week. Ten dated pregnancies were delivered at 74-100% of term, weighing 495-988 gms. They were managed with techniques and equipment used for human neonates. Of 9 preterm animals 6 had HMD by clinical and X-ray criteria and 3 survived to develop pathologically confirmed BPD. HMD was pathologically confirmed in 2 animals who died <1 week.

It appears that the major factors thought to contribute to the development of BPD in human neonates may also produce BPD in neonatal baboons: prematurity, HMD, high FIO2, IPPV and time. With the development of an animal model for BPD, the etiologic variables should be amenable to future investigation. (Supported by the Ladies Forum of the SWFRE)

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Escobedo, M., Robotham, J., Hilliard, J. et al. 1651 THE PRETERM BABOON WITH HYALINE MEMBRANE DISEASE (HMD) AS A MODEL FOR BRONCHOPULMONARY DYSPLASIA (BPD). Pediatr Res 15, 718 (1981) doi:10.1203/00006450-198104001-01668

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