Abstract
The gonadotrophin response to Gn-RH was studied in 18 males with nephrotic syndrome treated with cyclophosphamide in a total dosis ranging from 2 to 94gm. Evaluation was performed from 6 months to 10 years after completion of therapy. Patients were divided in 3 groups: a) 8 prepubertal (6 to 9y) b) 8 pubertal (11 to 17y) and c) 2 adults (20y). LH and FSH were measured by RIA and results given in ng/ml LER 907. Normal values in our laboratory are (X ± SD) basal (B) and maximal increment (MI):
B and and post Gn-RH gonadotrophin values did not differ significantly from controls. However, elevated FSH values were found in cne patient of group a, who received the highest cyclophosphamide dosage of this group. It is concluded that at the time of the study in 17/18 patients there was no testicular damage capable to produce a gonadotrophin elevation.
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Mendilaharzu, H., Caletti, M., Vitacco, M. et al. 13 GONADOTROPHIN RESPONSE TO Gn-RH IN PATIENTS TREATED WITH CYCLOPHOSPHAMIDE. Pediatr Res 15, 185 (1981). https://doi.org/10.1203/00006450-198102000-00070
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DOI: https://doi.org/10.1203/00006450-198102000-00070