Abstract
To determine the development of the lipid clearing mechanism, we have measured serum postheparin lipolytic activity (PHLA), triglyceride (TG) and free fatty acid (FFA) levels in 18 preterm infants, gestational age (G.A.) 25-32 wks, aged 16±1.5 days. Intralipid (I), 0.5 g/kg, was infused without or (after 1-4 days) with heparin (H), 10 U/kg for 4 h and blood was collected at 0, 10, 30, 120 and 240 min of infusion. PHLA (1 unit (U)=1 μmol FFA released from tri-3H olein/ml/h), TG and FFA were measured in all serum specimens. The data show:
1. TG clearing develops at 27-28 wks G.A.: PHLA is low <27 wks, highly variable at 27-28 wks and adequate >29 wks. 2. A single bolus of H has only a transient effect on I clearance. 3. PHLA may be depleted by prolonged I infusion-correlation between PHLA and cumulative I infused was r=-0.53, p<0.02 (n=18). We conclude that infants <28 wks G.A. are most susceptible to hepatic and pulmonary complications following prolonged I infusion. (Support NIH grant HL-19056)
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Dhanireddy, R., Hamosh, M., Sivasubramanian, K. et al. 1115 LIPID CLEARING IN PRETERM INFANTS: RELATIONSHIP OF LIPOLYTIC ACTIVITY TO GESTATIONAL AGE AND LIPID LOAD. Pediatr Res 15 (Suppl 4), 628 (1981). https://doi.org/10.1203/00006450-198104001-01141
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DOI: https://doi.org/10.1203/00006450-198104001-01141