Abstract
Guanosine 3′:5′ monophosphate (cGMP) and adenosine 3′:5′ monophosphate (cAMP) are known to participate in the regulation of cellular proliferation and differentiation, the processes intimately associated with neoplastic transformation. Plasma concentrations of both cGMP and cAMP were therefore examined in 32 patients with ALL at the time of diagnosis, during remission, and (in 4 cases) at relapse, and were compared to values determined on 65 controls matched for age. Blood was collected into EDTA tubes from supine and relatively calm children, plasma was quickly separated, frozen and kept at -60°C until assayed. The control group exhibited a significant decrease in plasma cGMP with increasing age whereas cAMP concentrations remained almost constant from the first through the tenth year. Plasma concentrations of cGMP in ALL patients at diagnosis were significantly higher than control values; the most pronounced difference was observed in the 7 - 10 year-old group which also showed elevated cAMP values. Both nucleotides decreased during the remission period and the recurrence of the disease coincided with another rise in cGMP values. Preliminary data indicate that plasma cGMP in ALL reflects the cGMP content of white cells but the significance of our results will have to emerge from further studies. However, if confirmed on a larger group of patients, the simple and inexpensive cGMP determinations may serve as another diagnostic test to help in early detection of subclinical recurrence of the disease. (Supported by B.C. Health Care Research Fdn.)
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Skala, J., Rogers, P. & Maclaren, I. 875 PLASMA CYCLIC NUCLEOTIDES IN CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIA (ALL). Pediatr Res 15 (Suppl 4), 588 (1981). https://doi.org/10.1203/00006450-198104001-00900
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DOI: https://doi.org/10.1203/00006450-198104001-00900