Abstract
Long-term survivors of ALL (n = 20; median 10 years) at City of Hope were evaluated with intelligence (WISC) and achievement (WRAT) tests and family interviews. They had been treated with rotational reinduction combination chemotherapy. CNS prophylaxis had consisted of 2400 R cranial irrad. + IT Mtx (16/20); craniospinal irrad. + IT Mtx (3/20); IT Mtx (1/20). Two children had experienced bacterial meningitis, 2 seizure disorders, 1 P. carinii pneumonitis.
WISC Verbal IQ was significantly low (mean 91.6). Poor performance on Information, Arithmetic and Digit Span subtests contributed to low Verbal IQ suggesting deficits in attention, concentration, long and short term memory skills. WRAT achievement scores were below average on Spelling and Arithmetic subtests (mean 90.4 and 84.6). 8/20 had repeated a grade. 8/20 had received special education or remedial instruction and 4/20 had been tutored. The results indicate that children with ALL in remission are at risk for learning difficulties and that the scholastic functioning of leukemia survivors should be closely monitored.
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Powazek, M., Rosen, R. & Pinkel, D. 854 INTELLECTUAL AND ACADEMIC STATUS OF LONG-TERM SURVIVORS OF ACUTE LYMPHOCYTIC LEUKEMIA (ALL). Pediatr Res 15 (Suppl 4), 585 (1981). https://doi.org/10.1203/00006450-198104001-00879
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DOI: https://doi.org/10.1203/00006450-198104001-00879