Abstract
LHRH was injected i.v. for 3 hours (0.55 μg/min.) in 12 C and 6 N children. Basal, peak and Δ FSH values were similar in C and N. In contrast, LH peak (4.1 ± 0.35 SEM mIU/ml) and Δ (2.5±0.35 mIU/ml) values in C were lower than those (11.5±1.15 ; 9.2±1.67 mIU/ml) found in N (p < 0.001). The above results were compared with those obtained after a single bolus injection of LHRH (100 μg/1.73 m2) in 72 C and 11 N. In C the LH peak was lower after infusion than following bolus injection (p < 0.005); no difference was observed in FSH peak. In N the infusion induced LH and FSH peaks higher than after the bolus (p < 0.005).
Therefore, LHRH infusion seems to be a more appropriate test than the single bolus injection for the recognition of LH defect in cryptorchidism.
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Vanelli, M., Bernasconi, S., Virdis, R. et al. Gonadotropine response to 3 hours LHRH infusion in cryptorchid (C) and normal (M) children. Pediatr Res 15, 88 (1981). https://doi.org/10.1203/00006450-198101000-00102
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DOI: https://doi.org/10.1203/00006450-198101000-00102