Abstract
Thirty five children with FH, treated with cholestyramine, but without dietary restriction, have been followed for 6-8 years. For those remaining on treatment group mean plasma cholesterol was lowered by 30% in the first year, on a mean dose of 0.4g/Kg/day. In subsequent years group mean reduction varied between 26% and 44%.
Compliance with treatment declined with time; after 4 years only 68% remained on treatment, and only 48% by the end of 8 years.
An attempt to identify factors influencing compliance in this group shows:
Compliance was better in those starting the drug before the age of 10 (p >0.025)
Compliance was not significantly better in those with a family history of premature IHD.
Compliance with cholestyramine was no worse than with a more palatable bile acid sequestrant (Secholex).
There was no sex difference in compliance rates.
Siblings all behaved concordantly.
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West, R. FAMILIAL HYPERCHOLESTEROLAEMIA. FACTORS INFLUENCING DRUG COMPLIANCE. Pediatr Res 14, 1423 (1980). https://doi.org/10.1203/00006450-198012000-00089
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DOI: https://doi.org/10.1203/00006450-198012000-00089