Abstract
(C) is an orally active anti-hypertensive which inhibits the conversion of angiotensin I (AI) to angiotensin (( (AII). We report 6 patients: 3 with renal failure on dialysis; 2 with vasculitis and 1 chronic renal transplant rejection. All were unresponsive to conventional therapy. Plasma renin activity (PRA) (ng/ml/hr), AI (pg/ml) and AII (pg/ml) levels were measured pre and post therapy.
In cases 1,2,4 (C) alone served to reduce blood pressure (BP). (C) decreased BP in 3 despite low renin levels, indicating at least 2 modes of action for (C). No significant side effects were noted. (C) is an effective, well-tolerated anti-hypertensive agent in children.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Friedman, A., Chesney, R., Ball, D. et al. CAPTORIL (C) -SUCCESSFUL USE IN SEVERE HYPERTENSION. Pediatr Res 14, 1009 (1980). https://doi.org/10.1203/00006450-198008000-00215
Issue Date:
DOI: https://doi.org/10.1203/00006450-198008000-00215