Abstract
C. was used in 18 Steroid-Resistant (SR) N and in 27 Steroid-Sensitive (SS)N. Two regimens were used: in the former a total dose of 0.8to1/mg/kg was given alone using 12 IV injections over one month. In the latter a total dose of 0.8 mg/kg was given over two periods of 4 days separated by one month, and was associated with Prednisone (2 mg/kg/day) and anti-emetic agents. In SRN, only one patient remitted, whereas 2 had a transient ( 2 weeks) and one a partial remission. The others were un changed. SSN were all steroid dependent and 13/27 had severe steroid toxicity signs. C. was given 0.5 to 11 years after onset. A remission was obtained in all but two patients treated with the first regimen. Remission lasted less than one year in 10, 1 to 2 years in 5. In the remainder, follow-up was less than 2 years, except for 4 children: one had a relapse 4 years later, and 3 had sustained remission 2,2 1/2 and 13 years after therapy. Of the 16 patients who relapsed, 6 received other nitrogen mustards and 10 were controlled using non toxic doses of alternate-day Prednisone therapy. Side effects were leucopenia (20%) including pancytopenia in 3 children and gastrointestinal disorders (50%). Only one patient was studied in adulthood and had a normal spermcount. In conclusion: C. was ineffective in SRN, and resulted mainly in short remissions in SSN. In SSN however, C. when associated with Prednisone seemsbeneficial in decreasing the dose of Prednisone required to maintain remission.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Lenoir, G., Kleinknecht, C., Guesry, P. et al. CHLORMETHINE (C) IN NEPHROSIS (N). Pediatr Res 14, 1006 (1980). https://doi.org/10.1203/00006450-198008000-00197
Issue Date:
DOI: https://doi.org/10.1203/00006450-198008000-00197