Abstract
It has been questioned that children with MC represent a different entity from those with FSS. We have studied the frequency of HLA antigens in 122 children with NS subdivided in 88 pts with MC and 34 with FSS. The MC pts were classified according to the frequency of relapses and the presence of atopy. HLA typing was performed using the NTH microlymphocytotoxicity technique. The p-values of the x2 test were corrected (pc) by multiplying them by the number of HLA-alleles testes. In MC HLA-B8 was significantly increased compared to controls (33% vs 18%, pc 0.05). In contrast to other reports, HLA-B12 was not more frequent in MC than in controls (25% vs 22%) but it was increased in FSS (35%). In MC HLA-B8 association seemed to be related to the clinical course: no or infrequent relapses: 26%, FR without steroiddependency: 27%: FR with steroiddependency:35%. HLA-B8 was more frequent in atopic than in non-atopic pts (38% vs 30%). These findings indicate that MC and FSS in children with NS are pathogenetically different disorders. An unfavorable clinical course seems to be more frequent in HLA-B8 positive MC patients.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Muller-Wiefel, D., Lenhard, V., Dippell, J. et al. HLA IN MINIMAL CHANGE NEPHROTIC SYNDROME(MC) AND FOCAL SEGMENTAL GLOMERULOSCLEROSIS (FSS). Pediatr Res 14, 1003 (1980). https://doi.org/10.1203/00006450-198008000-00179
Issue Date:
DOI: https://doi.org/10.1203/00006450-198008000-00179