Abstract
NS episodes (NSE) are occasionally associated with UTI. However, the effect of UTI on NS is not clearly understood. We compared the clinico-laboratory findings and progress in steroid therapy (ST) of 22 NSE which, at onset were not on ST and had UTI with those of 22 other NSE without UTI. These occurred in 11 of 41 patients during an average follow-up of 54 years. The two groups included 21 steroid sensitive (SS) and one resistant NSE. Diagnosis and ST were based on ISKDC protocol. Antibiotics were administered for UTI. The ↑ BP (> 2SD) proteinuria mg/m2/hr and other laboratory findings (mean ± 1SD) were:
In addition, the mean duration of proteinuria (17 days) in the UTI group was longer than those without UTI (P<0.01). NSE associated with UTI is characterized by ↑ BP, ↑ serum creatinine, higher ESR and serum cholesterol, lower GFR and serum albumin and more severe prolonged proteinuria. Recognition of these adverse effects may enhance management of NS.
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Khan, A., Patel, U. & Evans, H. EFFECTS OF URINARY TRACT INFECTION (UTI) ON IDIOPATHIC NEPHROTIC SYNDROME (INS). Pediatr Res 14, 999 (1980). https://doi.org/10.1203/00006450-198008000-00154
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DOI: https://doi.org/10.1203/00006450-198008000-00154