Abstract
Seventeen patients of MPGN have been followed for 1.5-7.5 years. The age at onset or discovery ranges from 3 to 25 years of age. Initially 9 had edema, 2 had anemia and hypertention and 15 had hypocomplementemia. Five had previous diagnosis of AGN, and 6 were nephrotic. In 9 patients abnormalities were found by routine annual urinalysis at school. Ten patients were treated with multiple small doses of steroid and immunosuppressants. None of these patients had so-called dense deposit disease. A 29 y/o nephrotic girl had intramembranous and subendothelial deposits which were characterized as segmental pattern. A 9 y/o boy had persistent hypocomplementemia although his initial hematuria and proteinuria have disappeared for 2 years. His renal biopsies showed subepithelial and mesangial deposits without any evidence for lupus nephritis serologically. Another 13 y/o girl had focal segmental GBM changes on initial specimen, which progressed to diffuse and global changes after 2 years. After a mean of 3.5 years follow-up one is in complete remission and one in CRF. Because of prevailing routine urinalysis at school, it becomes possible to detect and treat in its earlier stage of MPGN and this may give a clue to investigate pathogenesis of this disease.
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Ishidate, T., Iitaka, K. & Sakai, T. SERIAL PATHOLOGICAL CHANGES OF MPGN. Pediatr Res 14, 996 (1980). https://doi.org/10.1203/00006450-198008000-00140
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DOI: https://doi.org/10.1203/00006450-198008000-00140