Summary: Sodium octanoate in an 0.2 M solution was administered to rabbits by continuous slow IV infusion over 4 hr. Controls were given identical infusions of normal saline. The animals were then sacrificed, brains were removed, and specific areas were isolated and assayed for Na+K+ ATPase activity. Significant inhibition of regional Na+K+ ATPase activity was detected in cortex, thalamus, hypothalamus, pons, and medulla of rabbits given octanoate when compared to controls.
Speculation: Elevated serum concentrations of short-chain fatty acids may produce coma in patients with Reye's syndrome and hepatic encephalopathy by inhibition of cerebral Na+K+ ATPase activity with resultant disruption of normal transport across neuronal and glial membranes.
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Trauner, D. Regional Cerebral Na+K+ ATPase Activity following Octanoate Administration. Pediatr Res 14, 844–845 (1980). https://doi.org/10.1203/00006450-198006000-00014
- hepatic encephalopathy
- Na+K+ ATPase activity
- short-chain fatty acid