Abstract
Hypersulfataemia is a common finding in advanced CRF. In this study we determined SO4 in various stages of CRF in 20 non-dialysed children age 4-18 yrs. in relation to GFR, ERPF, other plasma electrolytes and acid base balance. SO4 was measured by precipitation with BaCl2 and subsequent atomic absorption spectrophotometry of Ba in the supernatant.GFR (CInulin) ranged between 4 and 66 (mean 28) ml/min/1.73 m2 BSA and ERPF (CPAH) between 13 and 305 (mean 125) ml/min/1.73 m2. In all cases SO4 was > 0.3 mM/1 (upper limit of normal) at GFR <45 ml/min/1.73 m2. SO4 raised exponentially with decreasing renal function to levels 10 times normal. Significant correlations were found between SO4 and CInulin (r = 0.92), CPAH (r = 0.87), serum creatinine (r = 0.74), BUN (r = 0.63) and inorganic phosphate (r = 0.73), respectively, whereas serum Ca and base excess failed to correlate with SO4. In conclusion, the increase of plasma SO4 seems to depend primarily on renal function and less on the nutritional state of the uremic child as expressed by BUN. The close correlation between Pi and SO4 may be an indicator for a possible role of sulfate metabolism in the pathogenesis of renal osteodystrophy.
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Michalk, D., Manz, F. & Schärer, K. RELATION BETWEEN PLASMA SULFATE (SO4), PHOSPHATE (Pi) AND RENAL FUNCTION IN CHILDREN WITH CHRONIC RENAL FAILURE (CRF). Pediatr Res 13, 85 (1979). https://doi.org/10.1203/00006450-197901000-00094
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DOI: https://doi.org/10.1203/00006450-197901000-00094