Abstract
The pattern of LH-RH evoked (50 μg/M2 i.v.) release of LH and FSH was analyzed quantitatively as well as qualitatively in 123 normal and in 286 endocrinologically sick pre-adult subjects to characterize the functional state of their gonadotostat. The common methods applied to assess this functional state are not adequate enough to differentiate the quantitative and qualitative patterns of response, and therefore a comparative examination was carried out for the peak increment,net increment, area under the time-response curve till the peak value and the cumulative response, ie, the total area under the time-response curve in each subject. As almost all the parameters were just-normally or log-normally distributed, statistical assessment was based on non-parametric Mann and Whitney test. The cumulative response and median comparison gave more meaningful data, based on the magnitude and shape of the release pattern, for an accurate differential diagnosis.
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Gupta, D., Blank, B., Eichner, M. et al. Quantitative and qualitative analysis of LH-RH test in normal and endocrinologically sick pre-adult subjects. Pediatr Res 13, 1196 (1979). https://doi.org/10.1203/00006450-197910000-00094
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DOI: https://doi.org/10.1203/00006450-197910000-00094