Abstract
The effect of antileukemic chemotherapy on glycemic and insulin response was investigated in 15 children (ages 2–12) with ALL after an oral glucose load.The glucose loading was performed prior to,and on days 8 and 19 of chemotherapy. The patients were randomly assigned to either Group I, receiving prednisone and Vincristine, or Group II receiving the same drugs and L-asparaginase (L-asp) from days 9 through 19 of treatment. At diagnosis and prior to initiation of therapy, 6 of 15 children (40%) had chemical diabetes according to the criteria of Guthrie. In all 6 children the carbohydrate tolerance improved after 1 week of prednisone and vincristine treatment,despite the expected diabetogenic effect of steroids. This probably indicates that the abnormal glucose tolerance noted in ALL is due to the disease process itself.No difference in glucose tolerance or insulin response curves was detected between Group I and Group II in the different phases of the study.No diabetogenic effect of L-asp.was observed in this study.
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Dacou-Voutetokis, C., Haidas, S., Georgiopoulou, P. et al. 10 ABNORMAL GLUCOSE TOLERANCE IN CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIA (ALL): THE EFFECT OF INDUCTION CHEMOTHERAPY. Pediatr Res 13, 949 (1979). https://doi.org/10.1203/00006450-197908000-00026
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DOI: https://doi.org/10.1203/00006450-197908000-00026