Abstract
Platelet aggregation was studied in 40 children with previously untreated ALL. The studies were performed in 5 groups: during the two-phase multiple drug induction therapy, the three phases of cyclic sequential maintenance therapy (6-MP, MTX and VCR/PRED pulses) and after cessation of chemotherapy (Klin. Pädiat. 189: 89, 1977).
There was a significant inhibition of the collagen-induced platelet aggregation (p <0.001) during the two months' period of induction chemotherapy. By the use of ADP as platelet aggregating agent the impairment of function was less evident (p < 0.05). The alteration of platelet function persisted during the first cycle of maintenance therapy (6-MP) and reappeared regularly during the VCR/PRED pulses to a lesser degree (p <0.05). The aggregation was normal during the MTX- and all further 6-MP-cycles. Our findings indicate that antileukemic drugs, especially VCR may act as platelet aggregation inhibitors. Bleeding episodes have not been observed during the periods of altered platelet aggregation. A critical evaluation of the results is difficult because of the possible influence of other factors.
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Gadner, H., Kersten, C., Odenwald, E. et al. 5 DEFECTIVE PLATELET AGGREGATION IN CHILDREN WITH ALL DURING INDUCTION AND MAINTENANCE CHEMOTHERAPY. Pediatr Res 13, 949 (1979). https://doi.org/10.1203/00006450-197908000-00021
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DOI: https://doi.org/10.1203/00006450-197908000-00021