Abstract
Blood pH, bicarbonate, PCO2, serum calcium, alkaline phosphatase, iPTH and red blood cell carbonic anhydrase activity were measured in 37 patients receiving anticonvulsants. Carbonix anhydrase (CA) was measured by immunoadsorbent method described previously (Kondo et al., Clin. Chim. Acta 60, 347, 1975). 10 out of 37 patients showed acidosis (pH <7.30, bicarbonate <19.0 mEq) in whome a high incidence of hypocalcemia, hyperactivity of alkaline phosphatase and a significantly reduced CA-B dependent activity and CA-B specific activity (P <0.01) were found. High iPTH levels were found in 13 patients, but this was not correlated with the acid-base balance status. The mainly used anticonvulsant was phenytoin. Drugs seemed to have a direct effect on CA-B activity. Metabolic acidosis might be one of the factors in causing a disturbance of calcium metabolism in these patients.
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Matsuda, I., Nagai, B., Kondo, T. et al. Metabolic acidosis in patients receiving anticonvulsants. Pediatr Res 13, 87 (1979). https://doi.org/10.1203/00006450-197901000-00108
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DOI: https://doi.org/10.1203/00006450-197901000-00108
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