Abstract
Both neutrophils (PMN) and monocytes (MONO) from patients with chronic granulomatous disease (CGD) phagocytize normally but fail to kill catalase-positive intracellular organisms. While studying candidacidal mechanisms, Lehrer observed differential killing of Candida species by CGD cells. C. albicans was not killed by PMN or MONO but PMN showed a normal or relatively intact ability to kill 2 strains (C. parapsilosis, C. pseudotropicalis) which could not be killed by MONO. Our interest in these divergent candidacidal abilities was enhanced when C. parapsilosis was recovered from a CGD blood culture. Using the dye-exclusion assay of Lehrer and Cline, it was found that the patient's PMN failed to kill not only C. albicans but also C. pseudotropicalis and 2 strains of C. parapsilosis, including his own isolate. Studies of cells from 5 boys with X-linked CGD (Pt) and normals (Nl) are summarized below. Results are expressed as mean % kill of ingested organisms in 1 hour; ( )=number of tests.
Thus in this series both CGD phagocytic cell types share the defective killing capacity for the catalase-positive Candida species tested.
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Smithwick, E., Pahwa, S., Kapadia, A. et al. 741 CANDIDACIDAL CAPACITY IN CHRONIC GRANULOMATOUS DISEASE. Pediatr Res 12 (Suppl 4), 487 (1978). https://doi.org/10.1203/00006450-197804001-00746
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DOI: https://doi.org/10.1203/00006450-197804001-00746