Abstract
We studied active ileal ion transport invitro in piglets with acute diarrhea caused by transmissible gastroenteritis(TGE)virus. This invasive enteritis, similar to infantile human rotavirus enteritis, is thought to affect mainly upper bowel. In shortcircuited ileum, 40 hrs after infection when diarrhea severe,net Na+ and Cl− flux decreased under basal conditions,failed to respond to glucose 30 mM. Virus antigen was detected by immune fluorescence in jejunum but also in ileal epithelium at 12 and 18 hrs; shed by 24 hrs and did not reappear. At 40 hrs, in ileum, villi shortened, crypts deepened, cell transit accelerated and enzymes of villus cells resembled normal crypt cells(↓thymidine kinase(TK), ↓ sucrase(S) and ↓ Na-K-ATPase). We conclude that ion transport in ileum,as in jejunum can be disturbed in viral enteritis,that these abnormalities result from viral invasion of the ileum, associated not with direct viral damage but with impaired enterocyte differentiation. Events in ileum, a consequence of direct infection probably not of reinfection by virus shed from proximal regions, are important determinants of viral diarrhea.
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Shepherd, R., Butler, D., Gall, D. et al. 469 DYNAMICS OF ALTERED ILEAL TRANSPORT IN VIRAL DIARRHEA. Pediatr Res 12 (Suppl 4), 442 (1978). https://doi.org/10.1203/00006450-197804001-00474
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DOI: https://doi.org/10.1203/00006450-197804001-00474