Abstract
Thirty children, ages 6 weeks to 7 years with persistent chronic diarrhea unresponsive to a variety of other therapeutic modalities were treated with food extract injections. Diagnosis was made by history, specific food challenges using in vivo C3 alteration as an indicator of sensitivity, and intradermal provocative food testing. Other possible causes were eliminated by stool and blood examinations, sweat chloride measurement, gastrointestinal radiography and when indicated, intestinal mucosal biopsy. In 13 patients there was significant failure to thrive. The number of foods tested ranged from 1 to 23. Sensitivity was demonstrated by wheal growth within a 10 minute period and or by induction of symptoms or physical reactions. All patients were found to be sensitive to one or more foods. A good to excellent therapeutic response as measured by cessation of diarrhea and in most improved growth occurred in 23 patients. In 3 patients food extract therapy was considered unsuccessful or marginally helpful; in two it was discontinued. Two patients did not return after a brief period of treatment. No serious reactions to the testing or treatment injections was observed.
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Sandberg, D. 466 TREATMENT OF CHRONIC DIARRHEA RELATED TO FOOD SENS I-TIVITY WITH FOOD EXTRACT INJECTIONS. Pediatr Res 12 (Suppl 4), 441 (1978). https://doi.org/10.1203/00006450-197804001-00471
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DOI: https://doi.org/10.1203/00006450-197804001-00471