Abstract
Ninety-eight infants fulfilled criteria for GI allergy after disaccharide tolerance tests and small bowel biopsy when indicated. Of 62 allergic to cow's milk, 58 developed soy and 24 gluten allergies. Of 10 initially allergic to soy, 10 were later allergic to milk and 7 to gluten. 20 children under 3 developed allergies after gastroenteritis: 20 to milk, 16 to soy and 4 to gluten. Nearly 30% of primary milk and 105 of soy allergic infants and 20% postgastroenteritis allergic infants had low or absent serum IgA (mean 8 mg%). Twelve per cent of milk allergic patients and 5% of those with secondary allergies had serum IgG less than 300 mg%. Two-thirds of the IgA deficient and all but 1 IgG deficient infant had normal levels by 15 months. Oral Cromolyn (DSCG) or placebo was used in a 90 day double blind crossover in 14: 10 responded to drug, 3 to placebo (p<01) and 1 attained tolerance on placebo. Discontinuation of drug resulted in exacerbation by 2 days in 4, by 14-21 days in 5 and 2 have been asymptomatic for 6 months. There were no hepatic, renal or hematologic impairments.
Food allergies in infants are frequently multiple and often are associated with immune deficiency. DSCG is an efficacious modality of treatment in children who require severe dietary restrictions.
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Kocoshis, S., Gryboski, J. 448 COMBINED GI ALLERGY AND IMMUNOGLOBULIN DEFICIENCY: ROLE OF CROMOLYN. Pediatr Res 12 (Suppl 4), 438 (1978). https://doi.org/10.1203/00006450-197804001-00453
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DOI: https://doi.org/10.1203/00006450-197804001-00453