Abstract
Osmolality of oral glucose-electrolyte solutions may be reduced without altering caloric content if glucose oligosaccharides (GOS) are substituted for glucose. To evaluate the effect of glucose vs GOS on gastric emptying in newborns, GOS were substituted for glucose in a 400 mosm glucose solution to reduce osmolality to 200 or 300 mosm. To assess the effect of osmolality alone on gastric emptying, a 200 mosm glucose solution was increased to 300 or 400 mosm by adding the nonmetabolized pentose xylose. Effect of glucose concentration alone was assessed by comparing 200 vs 400 mosm glucose solutions. On the second day of life, six groups of 5 healthy term newborns were fasted 3 hours. Sixty cc of the test solution containing 5g/1 polyethylene glycol 5000 (PEG) as a marker was instilled into the stomach. After 28 minutes, 3 mg of phenol red was instilled and allowed to equilibrate for 2 minutes. Contents were then aspirated and assayed for PEG and phenol red. The following milliliters of original solution remained in the stomach:
We conclude that osmolality does not effect gastric emptying in the range of 200-400 mosm in newborns and substitution of glucose by GOS will not enhance gastric emptying of infant formulas or infant glucose-electrolyte preparations.
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Antonson, D., Paxson, C., Vanderhoof, J. et al. 390 EFFECT OF GLUCOSE AND OSMOLALITY ON GASTRIC EMPTYING IN NEWBORNS. Pediatr Res 12 (Suppl 4), 428 (1978). https://doi.org/10.1203/00006450-197804001-00395
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DOI: https://doi.org/10.1203/00006450-197804001-00395