Abstract
A 9 2/12 male with McCune-Albright Syndrome and acromegaly (length-178cm) had continued elevation of growth hormone(GH) and prolactin(Pr) despite surgery and radiation for a Pituitary Adenoma at 7 11/12 yrs. He perspired freely and constantly needed larger shoes. His continued rapid growth(>10cm/yr) and severe fibrous dysplasia led to recurrent pathological fractures of his femurs. A 5 mo. trial of CB-154 was initiated. The results of sequential resting GH and Pr concentrations and an oral glucose tolerance test (OGTT) were:
CB-154 significantly lowered GH and Pr concentration, and improved the OGTT. While on CB-154 a 24 Urine excretion of hydroxyproline fell 10 fold; he perspired less, and his shoe size and length did not increase. However, left heel pad thickness did not change. No side effects from CB-154 were noted. CB-154 appears to be an effective supplementary form of therapy for acromegaly in childhood.
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Lightner, E., Winter, J. 310 BROMOCRYPTINE (CB-154) THERAPY IN CHILDHOOD ACROMEGALY. Pediatr Res 12 (Suppl 4), 415 (1978). https://doi.org/10.1203/00006450-197804001-00315
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DOI: https://doi.org/10.1203/00006450-197804001-00315