Abstract
Phototherapy is widely used for treatment of hyperbilirubinemia. Other substances circulating in the blood might be affected by such exposure to light. Two compounds were studied in the rabbit: gentamicin and riboflavin. The latter possesses a conjugated double bond structure which fluoresces at 445 nm (similar to bilirubin). Gentamicin is a commonly used antibiotic in neonates. Adult rabbits were shaved over back, flanks, and upper legs (>60% surface area). Riboflavin (50 mg) was injected I.P., gentamicin (2 mg/kg) I.V. Venous blood samples were obtained hourly for 6-8 hrs. During sampling periods animals were exposed to ambient light (control) and to a white light bank (6-7 μ watts/cm2 at 18 inches) as “phototherapy”. 4 weeks separated control and phototherapy period. Plasma concentrations were analyzed by least squares method for slope of line of best fit; β and t1/2 was calculated.
These data indicate no consistent alteration with phototherapy in vivo in the elimination phase of drug metabolism.
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Berlin, C., Gushue, M. & Lee, C. 230 EFFECT OF PHOTOTHERAPY ON THE ELIMINATION (β) PHASE 230 OF RIBOFLAVIN AND GENTAMICIN. Pediatr Res 12 (Suppl 4), 402 (1978). https://doi.org/10.1203/00006450-197804001-00235
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DOI: https://doi.org/10.1203/00006450-197804001-00235