Abstract
D has been used to stop premature labor. D(4mg/kg) was infused over 5 minutes to 7 anesthetized ewes at mean gestation of 141±1.5SE days. Post-infusion changes± SE of baseline maternal blood pressure(MBP), fetal carotid(FC)pH,pO2,O2 saturation(O2%),cerebral blood flow(CBF) and % increase (Δ%) are presented in this table:
Fetal BP showed no significant change. Fetal EEG showed either reduction of amplitude and frequency or isoelectricity in 3 of 5 non-hypoxic fetuses studied. Conclusion: D causes maternal hypotension,fetal hypoxia, acidosis, EEG changes and increased Δ% of CBF.
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Ayromlooi, J., Lipsitz, P. 229 MATERNAL AND FETAL HEMODYNAMIC AND FETAL BRAIN FUNCTION (EEG) EFFECTS OF MATERNAL INFUSION OF DIAZOXIDE(D). Pediatr Res 12 (Suppl 4), 402 (1978). https://doi.org/10.1203/00006450-197804001-00234
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DOI: https://doi.org/10.1203/00006450-197804001-00234