Abstract
D has been used to stop premature labor. D crosses the placenta. Bolus intravenous D(8.4mg/kg±0.57SE)was given near term to 6 fetal lambs during an acute experiment. Post-infusion changes ±SE of baseline fetal carotid(FC)pH,pO2,O2 saturation(O2%),pCO2,blood pressure(FBP) are presented in this table:
Isoelectric EEG occurred within 5 min. post D infusion in 3 experiments. Conclusion: D infusion into the fetus may cause hypoxia, acidosis and isoelectric EEG.
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Ayromlooi, J., Lipsitz, P. 228 FETAL HEMODYNAMIC AND BRAIN FUNCTION(EEG) EFFECTS OF DIAZOXIDE(D) INFUSION INTO THE OVINE FETUS. Pediatr Res 12 (Suppl 4), 401 (1978). https://doi.org/10.1203/00006450-197804001-00233
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DOI: https://doi.org/10.1203/00006450-197804001-00233