Abstract
The effect of furosemide (F) on gentamicin (GN) nephrotoxicity was examined in a dog model.
GN 10 mg/kg and F 2 mg/kg were given IM every 8 hours for 9 days. Elevation of BUN and serum creatinine values was earlier and more marked than in dogs given only GN. Serial percutaneous renal biopsies showed earlier and more severe renal injury in GN+F dogs. Increased activities of the urinary enzymes muramidase (MUR), B-glucuronidase (BG) and N-acetyl-glucosaminidase (NAG) were early signs of biopsy confirmed renal injury.
Furosemide appears to potentiate gentamicin nephrotoxicity, perhaps in relation to volume depletion. Elevated urinary enzyme activities provide an early clue to the onset of renal injury.
§Mean enzyme activity ± SEM expressed as U/mg of urinary creatinine. *p<.05, **p<.01 [compared to control or control (F) values].
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Adelman, R., Conzelman, G., Spangler, W. et al. 225 FUROSEMIDE POTENTIATED GENTAMICIN NEPHROTOXICITY. Pediatr Res 12 (Suppl 4), 401 (1978). https://doi.org/10.1203/00006450-197804001-00230
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DOI: https://doi.org/10.1203/00006450-197804001-00230