Abstract
To evaluate the effect of H and surgery on thyroid and hepatic function in the pregnant sheep, 14 date bred ewes from 104 to 134 days gestation were anesthetized with 0.5 to 1.5% H in nitrous oxide and oxygen. The surgical procedure began 15 minutes later and lasted from 2 to 2 1/2 hours. Serum samples were obtained prior to and at 1/2 hour intervals for 2 hours after the start of H and at 24 and 48 hours post-operatively (PO). Pre-operatively, the mean serum (±SEM) thyroxine (T4) and triiodothyronine (T3) levels were 3.9±0.2 μg/dl and 117±8.3 ng/dl, respectively. The mean serum T4 level remained unchanged during the operative procedure but was elevated at 24 and 48 hours PO. The mean serum T3 level was lower at 2 hours post-anesthesia (84.8±10.8 ng/dl, p<0.025) returning to the pre-operative level by 48 hours. The mean T3/T4 ratio was decreased at 2 and 24 hours post-anesthesia, but returned to the pre-operative level by 48 hours. Pre-operatively, the mean SGOT (±SEM) level was 8.5±2.9 IU/L and the SGPT (±SEM) level was 61.7±7.1 IU/L and remained unchanged during the operative procedure. The mean SGOT level was increased at 48 hours PO (21.4±3.8 IU/L, p<0.025) and the mean SGPT level increased at 24 hours (147.6±20.4 IU/L, p<0.001) and 48 hours(170.6±17.1 IU/L, p<0.001) PO. Conclusion: In the pregnant ewe during the 3rd trimester, surgery under H anesthesia affects serum T4 and T3 levels and T3/T4 ratio and hepatic function tests for 48 hours3PO.
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Erenberg, A., Radosevich, F., Kennedy, R. et al. 181 THE EFFECT OF HALOTHANE (H) ON THYROID AND HEPATIC FUNCTION IN THE PREGNANT EWE. Pediatr Res 12 (Suppl 4), 394 (1978). https://doi.org/10.1203/00006450-197804001-00186
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DOI: https://doi.org/10.1203/00006450-197804001-00186