Abstract
The role of renal ischemia in coarctation of the aorta (CA) was assessed by comparing levels of plasma renin activity (PRA) in 6 patients with CA and 13 pts with essential hypertension(EH) The patients with CA ranged from 2 months to 17 years of age and were not receiving medications at the time of study. All had clinical and arteriographic evidence of CA and demonstrated resting gradients from 20 to 110 mmHg across the CA. Samples for PRA were obtained from the right renal vein (R-PRA), the left renal vein (L-PRA) and the lower inferior vena cava (I-PRA) before (Pre-F) and ten minutes after (Post-F) the administration of intravenous furosemide (1 mg/Kg).
PRA (ng/ml/hr)was significantly higher in those with CA (P<.001 for all values). Furosemide increased PRA in both groups but the percentage increase was greater in those with EH (CA 35%; EH 100% for I-PRA). These results suggest an important role for the reninangiotensin system in the patients with CA.
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Roland, JM., Whelton, P., Russell, R. et al. 154 HYPERTENSION IN COAPTATION OF THE AORTA: THE ROLE OF THE RENIN-ANGIOTENSIN SYSTEM. Pediatr Res 12 (Suppl 4), 389 (1978). https://doi.org/10.1203/00006450-197804001-00159
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DOI: https://doi.org/10.1203/00006450-197804001-00159