Abstract
Eight week-old spontaneously hypertensive rats (SHR) and nor-motensive Kyoto-Wistar controls (WKY) were studied in order to determine the effect of hypertrophy on passive elastic left ventricular wall stiffness. After perfusion cooling and arrest, excised hearts were mounted on mitral and aortic cannulae and maintained in calcium-free Krebs solution (4°C). From multiple static pressure-volume cycles over a 0-10 mmHg pressure range, LV chamber distensibility (ΔV/ΔP) data were fitted to the equation P=A+Bexp[C(ΔV)]. Unstressed chamber volume (Vo) and LV mass (LVM) were then determined. Assuming a spherical geometry for the LV, elastic wall stiffness moduli, (Es) from linear elasticity theory and uniaxial stiffness (Us) on the basis of large deformation theory, were derived from the pressure volume data. At any given stress level, LV wall stiffness is greater in the young SHR than in WKY early in the development of myocardial hypertrophy and hypertension.
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Culpepper, W., Sodt, P. & Cutilletta, A. 94 LEFT VENTRICULAR WALL STIFFNESS IN YOUNG SPONTANEOUSLY HYPERTENSIVE RATS. Pediatr Res 12 (Suppl 4), 379 (1978). https://doi.org/10.1203/00006450-197804001-00099
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DOI: https://doi.org/10.1203/00006450-197804001-00099