Abstract
Patients with IBD have abnormalities in bone growth and mineralization. Malabsorption and drug treatment may affect calcium and vitamin D homeostasis. 53 patients with IBD were evaluated for abnormalities in mineral metabolism. Diagnosis, extent of involvement, and activity of disease were determined by clinical, xray, endoscopic, and biopsy data. 17 had ulcerative colitis (UC); 36 had regional enteritis (RE) with disease confined to the colon in only four. All patients had normal serum levels of total calcium, inorganic phosphorus, alkaline phosphatase, and transaminases. Serum 250HD level in ng/ml (mean ± 1SEM) for all patients with UC was 24.8 ± 1.2 (normal 15-35). The levels of 25OHD in UC patients with more severe disease and/or steroid treatment did not differ from those in remission. In contrast, patients with RE of moderate activity had a mean serum 25OHD level (14.4 ± 2.6) which was significantly different from RE patients in remission (25.0 ± 1.7, p<0.01) or with mild disease (23.9 ± 3.0, p<0.01). RE patients being treated with steroids had a mean level of 25OHD (18.6 ± 3.1) significantly lower than patients being treated with azulfadine alone (25.3 ± 2.1, p<0.05).
These data indicate that IBD of the colon does not affect vitamin D homeostasis; whereas significant small bowel involvement is associated with low serum 25OHD levels.
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Fleischman, A., Daum, F., Dinari, G. et al. 5 SERUM 25-HYDROXYVITAMIN D(250HD) LEVELS IN CHILDREN AND ADOLESCENTS WITH INFLAMMATORY BOWEL DISEASE (IBD). Pediatr Res 12 (Suppl 4), 364 (1978). https://doi.org/10.1203/00006450-197804001-00010
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DOI: https://doi.org/10.1203/00006450-197804001-00010