Abstract
17OH-progesterone (RIA), cortisol (isotope derivative technique), and ACTH (RIA) was measured at control visits during 18 months in 24 patients with cortisone treated CAH (all 21OH-deficiency, 14 were salt losers). - Treatment was not changed in 14 patients (dosage reduced in 1). 17OH-progesterone was increased in 2, cortisol and ACTH was normal in all 14 patients. In 9 patients the dosage was raised at 20 occasions. Pregnanetriol excretion was increased in all 20 occasions and 17-KS in 16. Contemporary blood values were abnormal: 17OH-progesterone was high in 14 of 20 occasions, cortisol was low in 7, and ACTH high in 2. - Taken as new diagnostic tests compared to the excretion of 17-KS and pregnanetriol, the predictive value of a positive test (I) and the predictive value of a negative test (II) was:
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Petersen, K. Serum 170H-progesterone, serum cortisol and plasma ACTH in the management of congenital adrenal hyperplasia. Pediatr Res 12, 159 (1978). https://doi.org/10.1203/00006450-197802000-00080
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DOI: https://doi.org/10.1203/00006450-197802000-00080