Abstract
17-Hydroxyprogesterone (17P), testosterone (T), androstenedione (A), progesterone (P), 17-ketosteroids (17KS) and prenanetriol (p'triol) were measured serially in 31 CAH patients. Infants and adolescent girls showed significant correlations between 17P and T, A, P, respectively (p<0.001). A 17P <200ng/dl (6nmol/1) was associated with normal T, A, and P levels. A 17P 200-1000ng/dl (6-30nmol/1) produced occasional abnormal levels; when>1000ng/dl (30nmol/l), other steroid levels were high (particularly p'triol). There was no correlation between 17P and T in adolescent males (p>0.25). In infants, there was a significant correlation between mean 17P and T and height velocity SDS (p < 0.01). First year height velocity showed a significant negative correlation with hydrocortisone dose (p < 0.01). The results show the benefit of serial 17P and T measurements in the longer term management of CAH.
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Hughes, I., Winter, J. & Brook, C. Steroid interrelationships in congenital adrenal hyperplasia (CAH). Pediatr Res 12, 156 (1978). https://doi.org/10.1203/00006450-197802000-00062
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DOI: https://doi.org/10.1203/00006450-197802000-00062