Abstract
PRA, plasma NE, plasma volume (PV) and extracellular fluid volume (ECF) were measured in the supine position and after 3 hours upright posture (PRA and NE) in 13 patients with PH aged 9 to 19 years. Patients were studied in the Clinical Research Center, on regular diets, off antihypertensive medications with simultaneously measured 24 hour urinary sodium. Results expressed as means ± S.E.M.
8 patients exhibited a normal renin response (NR) to postural stress; 5 patients had a significantly blunted renin response (BR). Age, mean arterial pressure, supine PRA, and bupine NE did not differ significantly between the two groups. However, the NE response to postural stress (ΔNE) was significantly less in the BR group. While ECF and 24 hour urinary sodium did not differ significantly between the NR and BR groups; PV was significantly expanded in the latter. These results suggest that some children with PH have a blunted renin and sympathetic response to postural stress. The expanded PV in these patients may contribute to the blunted response and to the maintenance of their hypertension.
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Mentser, M., Lieberman, E. & Dequattro, V. 1092 PRIMARY HYPERTENSION (PH) IN CHILDREN AND ADOLESCENTS A SUB-GROUP WITH BLUNTED PLASMA RENIN (PRA) AND NOREPINEPHRINE (NE) RESPONSE TO POSTURAL STRESS. Pediatr Res 12 (Suppl 4), 546 (1978). https://doi.org/10.1203/00006450-197804001-01098
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DOI: https://doi.org/10.1203/00006450-197804001-01098