Abstract
Sixty-seven patients with idiopathic, nephrotic syndrome underwent renal biopsy. All had minimal lesion by light microscopy. Immunopathologic studies for complement (C3) and immunoglobulins (IgG, IgM and IgA) were carried out in all the specimens.
The patients were divided according to their response to prednisone into steroid resistant (11), frequent relapser (39) and infrequent relapser (17). Immunofluorescent findings on renal biopsy were the following:
There was no correlation between the deposition of immunoglobulins and the pattern of response to prednisone. However, complement (C3) was found only in patients with a steroid resistant or frequent relapsing nephrotic syndrome (p < 0.05).
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Garin, E., Donnelly, W. & Richard, G. 1067 PATTERN OF RESPONSE TO PREDNISONE AND IMMUNOPATHOLOGIC FINDINGS IN PATIENTS WITH IDIOPATHIC, MINIMAL LESION, NEPHROTIC SYNDROME. Pediatr Res 12 (Suppl 4), 541 (1978). https://doi.org/10.1203/00006450-197804001-01073
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DOI: https://doi.org/10.1203/00006450-197804001-01073