Abstract
The purpose of this study was to determine distribution of IRBF in infant puppies in response to ES. Studies were performed in 18 mongrel puppies age 10-20 days. Cardiac output (CO), total renal blood flow (RBF) and IRBF was determined by dye dilution and the injection of 25 μ radiolabeled microspheres into the left ventricle. ES was produced by IV injection of 10 mgm/kg of E coli 0111 B4.
These data demonstrate that RBF falls significantly 5 min. after ES and begins to increase by 20 min. OC and IC flow is initially unchanged; in late ES, IC flow is maintained as a result of a significant fall in OC flow. This response of IRBF may play a role in renal functional response to ES.
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deLeon, L., Weiss, L., Moore, E. et al. 1058 INTRARENAL BLOOD FLOW (RBF) AFTER ENDOtOXIC SHOCK (ES). Pediatr Res 12 (Suppl 4), 540 (1978). https://doi.org/10.1203/00006450-197804001-01064
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DOI: https://doi.org/10.1203/00006450-197804001-01064