Abstract
The pharmacokinetic disposition of F was studied in 8 premature and full-term neonates with fluid overload using a one compartment model. Mean (±S.E.) birth weight was 2391.3 ± 289.9 g; gestational age was 35.0 ± 1.8 wks and postnatal age was 11.5 ± 5.9 days. BUN was 10.4 ± 1.5 mg/d1 and serum creatinine was 0.9 mg/d1. Following a single IV dose of F, (1-1.5 mg/kg) blood samples (0.2 ml/sample) were obtained from a heelstick or an arterial catheter at times 0, 0.5, 1,2,4,6,9,12 and 24 hrs and analyzed for F, measured by gas liquid chromatography. The mean (±S.E) volume of distribution was 829.2 ±118.9 ml.kg-1; T½ was 7.7 ± 1.0 h; elimination rate constant (Kel) was 0.102 ± 0.013h-1 and plasma clearance was 81.61 ± 14.98 ml.kg-1.h-1. Compared to the disposition of F in normal adults, aVd is almost 4-fold greater in the neonate with an 8-fold prolongation in plasma T½, an 8-fold decrease in Kel and a 2-fold decrease in plasma clearance. Neither gestational and postnatal age nor birth weight correlated with the pharmacokinetic variables. F had no effect on the reserve bilirubin binding capacity (RBBC) measured by sephadexgel filtration in 6 neonates (age 2.1 ± 0.3 d; weight 2329.9 ± 339.1 g). Mean RBBC 5 min before and 30-60 min after F were 6.2±0.2 and 6.8 ± 0.5 mg/d1 respectively. Slow F elimination may partly explain the prolonged diuretic and saluretic effect of F in the neonate. This must be taken into account whenever repetitive or chronic administration of F is used in the newborn infant.
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Aranda, J., Perez, J., Sitar, D. et al. 1045 PROTEIN BINDING AND PHARMACOKINETIC DISPOSITION OF FUROSEMIDE (F) IN NEWBORN INFANTS. Pediatr Res 12 (Suppl 4), 538 (1978). https://doi.org/10.1203/00006450-197804001-01051
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DOI: https://doi.org/10.1203/00006450-197804001-01051