Abstract
In aminal systems prolactin (HPL) increases 1,25 dihydroxy vitamin D (1,25(OH)2D) and decreases 24,25 dihydroxy vitamin D (24,25(OH)2D) synthesis. 24,25(OH)2D is low during pregnancy with normal serum PTH. During pregnancy, serum HPL and other hormones are increased, but during lactation only HPL remains elevated. We studied lactating mothers and non-lactating controls for 24,25(OH)2D, 250HD, PTH, HPL, calcium and magnesium at 6 weeks post partum. In nursing mother 24,25(OH)2D was significantly lower than normal or post partum controls. During lactation only there was an inverse correlation between HPL and 24,25(OH)2D (R=-.51) and PTH and 24,25(OH)2D (R=-.47). During lactation there was no correlation between 24,25(OH)2D and 250HD (R=.18). Thus, changes in vitamin D metabolism probably mediated by HPL and PTH may enable the lactating woman to maintain normal serum calcium and magnesium while providing for milk production.
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Hillman, L., Sateesha, S., Slatopolsky, E. et al. 859 SERUM 24,25 DIHYDROXY VITAMIN D CONCENTRATIONS IN LACTATING AND NON-LACTATING POST PARTUM WOMEN. Pediatr Res 12 (Suppl 4), 507 (1978). https://doi.org/10.1203/00006450-197804001-00864
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DOI: https://doi.org/10.1203/00006450-197804001-00864