Abstract
The possibility that survivors of Reye's-like syndromes may be metabolically unique was explored by examination of their ability to mobilize metabolic fuels under endogenous and exogenous stimuli. 4 children, aged 5½, 8 10/12. 12 and 14½ years at the time of the acute disease were studied 1/3-3 years later. Oral glucose tolerance tests after 3-days CHO loading were abnormal: 3 had higher glucose and insulin and all had higher glucagon levels than normals. Fasting insulin and glucagon levels without CHO loading were repeatedly high and molar ratios were lower than normal in all. Glucose levels after epinephrine, glucagon and insulin were variable. The youngest child who received the max, recommended dose of epinephrine developed acute hepatomegaly (5cm below the RCM over a 3-4 hour period). Usual liver function studies were normal and enlargement was verified by technicium scintiangiography. Fasting glucose, insulin or glucagon levels were high in 3 of 4 parents and 1 of 2 asymptomatic siblings. These results indicate that these survivors are metabolically abnormal in their regulation of glucose and glucose substrates. It is likely that this was present prior to the acute disease, and we postulate that it imparts a risk for such a syndrome. Supported by USPHS NIH Grants HD09469, GAO5176, AM18022 & VAMRIS 8036 & 1942.
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Kang, E., Schwenzer, K., Solomon, S. et al. ABNORMAL REGULATION OF CALORIC HOMEOSTATIC IN REYE'S SYNDROME SURVIVORS. Pediatr Res 11, 516 (1977). https://doi.org/10.1203/00006450-197704000-00878
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DOI: https://doi.org/10.1203/00006450-197704000-00878