Abstract
LCMV infection of adult mice is the classic example of an immunopathologic disease, in that the cell mediated immune response of the host causes the disease.
We have seen a 2 1/2-year-old female with chronic meningitis of 80 days' duration manifested by fatigue, lethargy, CSF pleocytosis and high spiking fevers. A peripheral eosinophilia (1,472-2, 688 cells/mm3) and CSF eosinophilia (3-25%) were found during a one-month hospitalization at the height of her illness. Fourfold rises in CF, Neut. and Fluorescent antibody titers established LCMV as the cause. Extensive evaluations for parasitic or other CNS or systemic disease were unrevealing.
T & B cell function and macrophage studies were normal during her illness. During a documented intercurrent influenza A/ Victoria infection the following values were found:
This is the first known report of prolonged fever, eosinophilia and chronic eosinophilic meningitis due to LCMV.
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Chesney, P., Katcher, M., Nelson, D. et al. CHRONIC EOSINOPHILIC MENINGITIS DUE TO LYMPHOCYTIC CHORIOMENINGITIS VIRUS (LCMV). Pediatr Res 11, 497 (1977). https://doi.org/10.1203/00006450-197704000-00765
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DOI: https://doi.org/10.1203/00006450-197704000-00765