Abstract
During a measles immunization campaign blood samples were collected from 203 children before vaccination. Follow up specimens were collected from 125 children 3 wks. later and from 88 children 10 mos. later. Of the 125 children with follow up study, 88 had been previously vaccinatedt 10 had a history of measles and 27 denied vaccination or illness. Measles HAT antibody geometric mean liters (GMTs) were 13, (day 0), 38 (3 wks.), and 23 (10 mos.). Twenty-six of the 125 had HAI liters of – 5 prior to vaccination and showed a ≥4-fold antibody titer rise. IgM measles antibody was detected in 12 of these children after protein-A and 2-ME treatment with a GMT at 3 weeks and 10 months of 61 and 40 respectively. There was no history of measles exposure or vaccination in this group. In the remaining 14 children with initial titers < 5 no IgM antibody response was detected, and despite a 4-fold increase in HAI titer at 3 wks. (GMT 28), the 10 month titer had dropped considerably (GMT 9). Ten of these 14 children had a history of previous measles vaccination. The remaining 99 children had detectable initial titers between 5 and 320. After grouping these according to their pre-booster titers, no significant change in GMTs was observed when day 0, 3 wk. and 10 mo. results were compared. Our study suggests that HAI antibody titers in children previously immunologically stimulated against measles are not altered significantly by revaccination, even when the pre-booster titers are low or not detectable.
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Deseda-Tous, J., Cherry, J., Spencer, M. et al. MEASLES REVACCINATION; THE PERSISTENCE AND DEGREE OF ANTIBODY RESPONSE ANALYZED BY TYPE OF IMMUNE RESPONSE. Pediatr Res 11, 486 (1977). https://doi.org/10.1203/00006450-197704000-00695
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DOI: https://doi.org/10.1203/00006450-197704000-00695