Abstract
In 14 patients with Hodgkin's disease, aged 5½ to 19½ years, physical growth, immune status, thyroid function and pulmonary function were studied 1½ to 5 years after receiving extended field radiation ± combination chemotherapy in order to determine early evidence of tissue damage.
Eight of the 14 patients maintained the same height percentile or better, 13 maintained the same sitting height percentile whereas the bi-cristal and bi-deltoid diameter was in the same percentile in all patients. Eleven patients reacted to PPD, candida or to SKSD antigens whereas 3 remained anergic despite repeated testing. The IgG, IgA and IgM levels and the absolute lymphocyte count in each patient was within the normal range for age. In 2 patients with lymphocytopenia at the time of diagnosis the absolute lymphocyte count rose to normal levels following therapy. With reference to thyroid function 13 patients had normal T4 levels (range 3.0-5.3 ugm/dl) and 11 had normal TSH levels (range 4.0-9-8 microU/ml). The one patient who had a lowered T4 level also had a markedly elevated TSH level as evidence of thyroid hypofunction and these biochemical parameters returned to normal on thyroid therapy. Pulmonary function tests (FEV1 and VC) revealed 2 patients with severe and 2 with mildly compromised pulmonary function.
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Betkerur, U., Lanzkowsky, P. & Shende, A. TISSUE DAMAGE IN HODGKIN'S DISEASE FOLLOWING THERAPY. Pediatr Res 11, 467 (1977). https://doi.org/10.1203/00006450-197704000-00586
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DOI: https://doi.org/10.1203/00006450-197704000-00586