Abstract
The essential fatty acids (EFA) are incorporated into biological membranes and serve as prostaglandin (PCS) precursors. Plasma, RBC and tissues were analyzed in 2 neonates receiving total parenteral nutrition (TPN) for the first 11 weeks and in 3 controls fed breast milk (1) or formula (2). TPN included intralipid (IL-50% of which is linoleic acid) 1-4 gms/kg/24 hrs. Analysis of phospholipids, cholesterol esters, free fatty acids and triglycerides by TLC and GLC revealed that: (1) plasma, RBC and tissues from infants receiving IL contained higher levels of linoleic acid compared with controls (p< 0.001); (2) the higher polyenoic acid derivatives of linoleic acid, Δ-8,11,14 eicosatrienoic and arachidonic acids were lower in infants receiving IL (p<0.001); (3) the sum of the FA belonging to the linoleic acid series were similar in both groups. PGEM levels were lower in infants receiving iL (p<0.01) as compared with controls. Histological examination of lung tissues from both infants receiving IL revealed numerous globules of sudanophilic material in septal capillaries and in the cytoplasm of septal macrophages. Plasma lipid content was not elevated. Both infants required assisted ventilation. Further study is needed to evaluate the effects of PFE on biomembranes, PCS biosynthesis, lung capillary RBC investment and gas exchange.
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Friedman, Z., Lamberth, E., Frolich, J. et al. THE EFFECT OF PARENTERAL FAT EMULSIONS (PFE) ON TISSUE FATTY ACID COMPOSITION, THE MAJOR URINARY METABOLITES OF E PROSTAGLANDINS (PGEM) AND LUNG HISTOLOGY. Pediatr Res 11, 443 (1977). https://doi.org/10.1203/00006450-197704000-00444
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DOI: https://doi.org/10.1203/00006450-197704000-00444